Biosens

bSens Strips

The strip

The reactive strip. Each test is a bSens strip configured for what it measures or detects. For bSens.INR, that is clotting time.

  • Each test's page gives its stage and says whether its intended use is defined yet.
A bSens.INR strip held in a gloved hand.

bSens platform

  • Biomarker: What the drop reveals. For bSens.INR, clotting time.

  • Reagent: The chemistry on the strip that reacts with the sample.

  • Electrode: The sensor printed on the strip that turns the reaction into a signal.

One platform, designed for several tests.

The same reader and the same architecture are designed to grow from INR to other tests.

TRL, or technology readiness level, is a scale from 1 to 9 that shows a technology's stage of development. It does not indicate how a test performs.

  • bSens.INR

    Coagulation · PT/INR

    In preparation for registration

    Point-of-care strip test that uses graphene to measure prothrombin time, expressed as the PT/INR value (International Normalized Ratio).

  • bSens.LAC

    Lactate

    RoadmapTechnology readiness level 5 of 9

    A graphene-based strip test for measuring lactate at the point of care, planned for the same bSens One reader and architecture.

  • bSens.SYPH

    Syphilis

    RoadmapTechnology readiness level 5 of 9

    A point-of-care strip test with nanoparticles, in development for syphilis.

  • bSens.SMA

    Spinal muscular atrophy (SMA)

    RoadmapTechnology readiness level 4 of 9

    A point-of-care strip test with single-domain antibodies, in development for spinal muscular atrophy.

  • bSens.CARBA

    Carbapenem-resistant bacteria

    RoadmapTechnology readiness level 3 of 9

    A point-of-care strip test with CRISPR, in development for carbapenem-resistant bacteria.

  • bSens.SPEX

    Standard electrochemical sensor

    Research use

    Standard electrochemical sensor strips for assay development.

    For research use only. Not for use in diagnostic procedures.

Scientific context

What the studies say.

Data from scientific papers and books. They describe the condition, the field and the technology, not bSens products.

  • In an electrochemical biosensor, a biological component recognizes the substance being measured. That recognition produces an electrical signal, proportional to its concentration, which a transducer monitors. 1

  • Commercial screen-printed strips for glucose self-monitoring appeared in the 1980s. By 2010, most point-of-care glucose biosensors used disposable strips with screen-printed enzyme electrodes. 2

  • Screen-printed electrodes are single-use devices and can be mass-produced with reproducible surfaces. The production of these reproducible, disposable electrodes has had a profound impact on the development of electrochemical biosensors. 3,4

  • In graphene, the high surface-to-volume ratio allows more recognition molecules to be attached, and the high conductivity supports sensitive electrical and electrochemical read-outs. 5

  • Among graphene-based biosensors described in the literature, electrochemical detection is the most common. 6

  • A 2018 review of graphene biosensors notes that, because nanomaterial-based sensor designs were recent, there were no detailed reports of accuracy, precision, or positive and negative predictive values. The authors ask future studies to take these parameters into account. 6

References

  1. 1.Ronkainen NJ, Halsall HB, Heineman WR. Electrochemical biosensors. Chem Soc Rev. 2010;39:1747-1763. doi:10.1039/b714449k
  2. 2.Yoo EH, Lee SY. Glucose biosensors: an overview of use in clinical practice. Sensors (Basel). 2010;10:4558-4576. doi:10.3390/s100504558
  3. 3.Yamanaka K, Vestergaard MC, Tamiya E. Printable Electrochemical Biosensors: A Focus on Screen-Printed Electrodes and Their Application. Sensors (Basel). 2016;16:1761. doi:10.3390/s16101761
  4. 4.Mincu NB, Lazar V, Stan D, et al. Screen-Printed Electrodes (SPE) for In Vitro Diagnostic Purpose. Diagnostics (Basel). 2020;10:517. doi:10.3390/diagnostics10080517
  5. 5.Szunerits S, Boukherroub R. Graphene-based biosensors. Interface Focus. 2018;8:20160132. doi:10.1098/rsfs.2016.0132
  6. 6.Peña-Bahamonde J, Nguyen HN, Fanourakis SK, Rodrigues DF. Recent advances in graphene-based biosensor technology with applications in life sciences. J Nanobiotechnology. 2018;16:75. doi:10.1186/s12951-018-0400-z

Contact

Results at the Point of Care

Get in touch to learn about the bSens system.

Please do not send health information by e-mail. Biosens does not interpret test results or guide treatment.

E-mail

contact@biosens.tech

Address

Av. Theodomiro Porto da Fonseca 3101, Building 3, Room 1, 93022-715, São Leopoldo, RS, Brazil